5-Aminovaleric Acid Suppresses the Development of Severe Seizures in the Methionine Sulfoximine Model of Mesial Temporal Lobe Epilepsy

Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of drug-resistant, localization-related epilepsies in humans. One potential therapeutic target is the brain glutamine-glutamate-GABA metabolic pathway, which is perturbed in patients with MTLE. Loss of glutamine synthetase (GS) in...

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Hauptverfasser: Dhaher, Roni, Damisah, Eyiyemisi C, Wang, Helen, Gruenbaum, Shaun, Ong, Caroline, Zaveri, Hitten P, Gruenbaum, Benjamin, Eid, Tore
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035438/
https://ncbi.nlm.nih.gov/pubmed/24632421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.03.006
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