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Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy

Glutamine synthetase (GS) in astrocytes is critical for metabolism of glutamate and ammonia in the brain, and perturbations in the anatomical distribution and activity of the enzyme are likely to adversely affect synaptic transmission. GS is deficient in discrete regions of the hippocampal formation...

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Опубликовано в: :Epilepsy Res
Главные авторы: Dhaher, Roni, Wang, Helen, Gruenbaum, Shaun E, Tu, Nathan, Lee, Tih-Shih W, Zaveri, Hitten P, Eid, Tore
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677790/
https://ncbi.nlm.nih.gov/pubmed/26220375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2015.05.005
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