Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy

Glutamine synthetase (GS) in astrocytes is critical for metabolism of glutamate and ammonia in the brain, and perturbations in the anatomical distribution and activity of the enzyme are likely to adversely affect synaptic transmission. GS is deficient in discrete regions of the hippocampal formation...

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Gepubliceerd in:Epilepsy Res
Hoofdauteurs: Dhaher, Roni, Wang, Helen, Gruenbaum, Shaun E, Tu, Nathan, Lee, Tih-Shih W, Zaveri, Hitten P, Eid, Tore
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677790/
https://ncbi.nlm.nih.gov/pubmed/26220375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2015.05.005
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