Serum C-telopeptide collagen crosslinks and plasma soluble VEGFR2 as pharmacodynamic biomarkers in a trial of sequentially administered sunitinib and cilengitide

BACKGROUND: Fit-for-purpose pharmacodynamic biomarkers could expedite development of combination anti-angiogenic regimens. Plasma sVEGFR2 concentrations ([sVEGFR2]) mark sunitinib effects on the systemic vasculature. We hypothesized that cilengitide would impair microvasculature recovery during suni...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: O’Donnell, Peter H., Karovic, Sanja, Karrison, Theodore G., Janisch, Linda, Levine, Matthew R., Harris, Pamela J., Polite, Blase N., Cohen, Ezra E.W., Fleming, Gini F., Ratain, Mark J., Maitland, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677671/
https://ncbi.nlm.nih.gov/pubmed/26199386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0427
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