Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib

PURPOSE: Vascular endothelial growth factor receptor (VEGFR) kinases are important drug targets in oncology that affect function of systemic endothelial cells. To discover genetic markers that affect VEGFR inhibitor pharmacodynamics we performed a genome-wide association study of serum soluble vascu...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Maitland, Michael L., Xu, Chun-Fang, Cheng, Yu-Ching, Kistner-Griffin, Emily, Ryan, Kathleen A., Karrison, Theodore G., Das, Soma, Torgerson, Dara, Gamazon, Eric, Thomeas, Vasiliki, Levine, Matthew R., Wilson, Paul A., Bing, Nan, Liu, Yuan, Cardon, Lon R., Pandite, Lini N., O’Connell, Jeffrey R., Cox, Nancy J., Mitchell, Braxton D., Ratain, Mark J., Shuldiner, Alan R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323272/
https://ncbi.nlm.nih.gov/pubmed/25411163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1683
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