Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib

PURPOSE: Vascular endothelial growth factor receptor (VEGFR) kinases are important drug targets in oncology that affect function of systemic endothelial cells. To discover genetic markers that affect VEGFR inhibitor pharmacodynamics we performed a genome-wide association study of serum soluble vascu...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Maitland, Michael L., Xu, Chun-Fang, Cheng, Yu-Ching, Kistner-Griffin, Emily, Ryan, Kathleen A., Karrison, Theodore G., Das, Soma, Torgerson, Dara, Gamazon, Eric, Thomeas, Vasiliki, Levine, Matthew R., Wilson, Paul A., Bing, Nan, Liu, Yuan, Cardon, Lon R., Pandite, Lini N., O’Connell, Jeffrey R., Cox, Nancy J., Mitchell, Braxton D., Ratain, Mark J., Shuldiner, Alan R.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323272/
https://ncbi.nlm.nih.gov/pubmed/25411163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1683
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