Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib

PURPOSE: Vascular endothelial growth factor receptor (VEGFR) kinases are important drug targets in oncology that affect function of systemic endothelial cells. To discover genetic markers that affect VEGFR inhibitor pharmacodynamics we performed a genome-wide association study of serum soluble vascu...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Maitland, Michael L., Xu, Chun-Fang, Cheng, Yu-Ching, Kistner-Griffin, Emily, Ryan, Kathleen A., Karrison, Theodore G., Das, Soma, Torgerson, Dara, Gamazon, Eric, Thomeas, Vasiliki, Levine, Matthew R., Wilson, Paul A., Bing, Nan, Liu, Yuan, Cardon, Lon R., Pandite, Lini N., O’Connell, Jeffrey R., Cox, Nancy J., Mitchell, Braxton D., Ratain, Mark J., Shuldiner, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323272/
https://ncbi.nlm.nih.gov/pubmed/25411163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1683
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