Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo

The ubiquitin–proteasome pathway plays a critical role in the intracellular trafficking of recombinant adeno-associated virus 2 (AAV2) vectors, which negatively impacts the transduction efficiency of these vectors. Because ubiquitination occurs on lysine (K) residues, we performed site-directed muta...

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Bibliographic Details
Published in:Hum Gene Ther Methods
Main Authors: Li, Baozheng, Ma, Wenqin, Ling, Chen, Van Vliet, Kim, Huang, Lin-Ya, Agbandje-McKenna, Mavis, Srivastava, Arun, Aslanidi, George V.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677520/
https://ncbi.nlm.nih.gov/pubmed/26421998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2015.115
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