High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines

Elimination of specific surface-exposed single tyrosine (Y) residues substantially improves hepatic gene transfer with adeno-associated virus type 2 (AAV2) vectors. Here, combinations of mutations in the seven potentially relevant Y residues were evaluated for further augmentation of transduction ef...

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Main Authors: Markusic, David M, Herzog, Roland W, Aslanidi, George V, Hoffman, Brad E, Li, Baozheng, Li, Mengxin, Jayandharan, Giridhara R., Ling, Chen, Zolotukhin, Irene, Ma, Wenqin, Zolotukhin, Sergei, Srivastava, Arun, Zhong, Li
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997584/
https://ncbi.nlm.nih.gov/pubmed/20736929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.172
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