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Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase
[Image: see text] Studies of triazole bisphosphonates have resulted in identification of a potent inhibitor of geranylgeranyl diphosphate synthase (IC(50) = 45 nM) with very good selectivity for this enzyme over farnesyl diphosphate synthase (IC(50) = 28 μM). This compound also potently disrupts ger...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2015
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4677368/ https://ncbi.nlm.nih.gov/pubmed/26713103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00334 |
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