Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

[Image: see text] Herein, the synthesis and biological evaluation of dual opioid agonists–neurokinin 1 receptor (NK1R) antagonists is described. In these multitarget ligands, the two pharmacophores do not overlap, and this allowed maintaining high NK1R affinity and antagonist potency in compounds 12...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Betti, Cecilia, Starnowska, Joanna, Mika, Joanna, Dyniewicz, Jolanta, Frankiewicz, Lukasz, Novoa, Alexandre, Bochynska, Marta, Keresztes, Attila, Kosson, Piotr, Makuch, Wioletta, Van Duppen, Joost, Chung, Nga. N., Vanden Broeck, Jozef, Lipkowski, Andrzej W., Schiller, Peter W., Janssens, Frans, Ceusters, Marc, Sommen, François, Meert, Theo, Przewlocka, Barbara, Tourwé, Dirk, Ballet, Steven
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2015
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677362/
https://ncbi.nlm.nih.gov/pubmed/26713106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00359
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items