Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

[Image: see text] Herein, the synthesis and biological evaluation of dual opioid agonists–neurokinin 1 receptor (NK1R) antagonists is described. In these multitarget ligands, the two pharmacophores do not overlap, and this allowed maintaining high NK1R affinity and antagonist potency in compounds 12...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Betti, Cecilia, Starnowska, Joanna, Mika, Joanna, Dyniewicz, Jolanta, Frankiewicz, Lukasz, Novoa, Alexandre, Bochynska, Marta, Keresztes, Attila, Kosson, Piotr, Makuch, Wioletta, Van Duppen, Joost, Chung, Nga. N., Vanden Broeck, Jozef, Lipkowski, Andrzej W., Schiller, Peter W., Janssens, Frans, Ceusters, Marc, Sommen, François, Meert, Theo, Przewlocka, Barbara, Tourwé, Dirk, Ballet, Steven
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677362/
https://ncbi.nlm.nih.gov/pubmed/26713106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00359
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