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Development and Mechanism of an Enantioselective Bromocycloetherification Reaction via Lewis Base/Chiral Brønsted Acid Cooperative Catalysis

The development of a binary catalyst system for bromocycloetherification, consisting of an achiral Lewis base and a chiral Brønsted acid, is described in detail. The results of preliminary kinetic studies are also presented.

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Bibliographic Details
Published in:Chirality
Main Authors: DENMARK, SCOTT E., BURK, MATTHEW T.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676414/
https://ncbi.nlm.nih.gov/pubmed/24395341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chir.22259
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