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Conformational Transitions in Human AP Endonuclease 1 and Its Active Site Mutant during Abasic Site Repair
AP endonuclease 1 (APE 1) is a crucial enzyme of the base excision repair pathway (BER) in human cells. APE1 recognizes apurinic/apyrimidinic (AP) sites and makes a nick in the phosphodiester backbone 5′ to them. The conformational dynamics and presteady-state kinetics of wild-type APE1 and its acti...
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| Gepubliceerd in: | Biochemistry |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4676079/ https://ncbi.nlm.nih.gov/pubmed/20575528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100769k |
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