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Repression of AKT signaling by ARQ 092 in cells and tissues from patients with Proteus syndrome
A somatic activating mutation in AKT1, c.49G>A, pGlu17Lys, that results in elevated AKT signaling in mutation-positive cells, is responsible for the mosaic overgrowth condition, Proteus syndrome. ARQ 092 is an allosteric pan-AKT inhibitor under development for treatment in cancer. We tested the e...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4675973/ https://ncbi.nlm.nih.gov/pubmed/26657992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17162 |
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