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Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically important functions: reduction of reactive oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). How Sestrins fulfil this dual role has remained elusive so far...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4674687/ https://ncbi.nlm.nih.gov/pubmed/26612684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10025 |
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