Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically important functions: reduction of reactive oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). How Sestrins fulfil this dual role has remained elusive so far...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Kim, Hanseong, An, Sojin, Ro, Seung-Hyun, Teixeira, Filipa, Jin Park, Gyeong, Kim, Cheal, Cho, Chun-Seok, Kim, Jeong-Sig, Jakob, Ursula, Hee Lee, Jun, Cho, Uhn-Soo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Pub. Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674687/
https://ncbi.nlm.nih.gov/pubmed/26612684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10025
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