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The p53-regulated Sestrin gene products inhibit mTOR signaling
Tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR whose activity is controlled by the TSC1:TSC2 complex, a GTPase activating protein (GAP) fo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758522/ https://ncbi.nlm.nih.gov/pubmed/18692468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.06.028 |
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