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Recombinant Immunotoxin with T Cell Epitope Mutations that Greatly Reduce Immunogenicity for Treatment of Mesothelin Expressing Tumors
SS1P is a recombinant immunotoxin (RIT) that targets mesothelin. It consists of an anti-mesothelin Fv fused to a portion of Pseudomonas exotoxin A. In clinical studies it has produced dramatic responses in patients with advanced mesothelioma, when combined with immunosuppressive therapy so that seve...
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| Publicado no: | Mol Cancer Ther |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4674367/ https://ncbi.nlm.nih.gov/pubmed/26443804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0532 |
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