Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model

Triple-negative breast cancers (TNBCs) are typically resistant to treatment, and strategies that build upon frontline therapy are needed. Targeting the murine double minute 2 (Mdm2) protein is an attractive approach as Mdm2 levels are elevated in many therapy-refractive breast cancers. The Mdm2 prot...

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Publicat a:Mol Cancer Ther
Autors principals: Tonsing-Carter, Eva, Bailey, Barbara J., Saadatzadeh, M. Reza, Ding, Jixin, Wang, Haiyan, Sinn, Anthony L., Peterman, Kacie M., Spragins, Tiaishia K., Silver, Jayne M., Sprouse, Alyssa A., Georgiadis, Taxiarchis M., Gunter, T. Zachary, Long, Eric C., Minto, Robert E., Marchal, Christophe C., Batuello, Christopher N., Safa, Ahmad R., Hanenberg, Helmut, Territo, Paul R., Sandusky, George E., Mayo, Lindsey D., Eischen, Christine M., Shannon, Harlan E., Pollok, Karen E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674357/
https://ncbi.nlm.nih.gov/pubmed/26494859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0237
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