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A Hypothesis Concerning the Biphasic Dose-response of Tumors to Angiostatin and Endostatin

This manuscript proposes a hypothesis to explain the U-shaped dose-response observed for angiostatin and other high-molecular-weight drugs in various anti-cancer bio-assays. The dose-response curves for angiostatin and endostatin (measured as suppression of tumor growth) go through an optimum (i.e.,...

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Vydáno v:Dose Response
Hlavní autor: Parris, George E.
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674172/
https://ncbi.nlm.nih.gov/pubmed/26675544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2203/dose-response.14-020.Parris
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