A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity

Centromere-associated protein E (CENP-E) regulates both chromosome congression and the spindle assembly checkpoint (SAC) during mitosis. The loss of CENP-E function causes chromosome misalignment, leading to SAC activation and apoptosis during prolonged mitotic arrest. Here, we describe the biologic...

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Publicat a:PLoS One
Autors principals: Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Nambu, Tadahiro, Miyamoto, Maki, Kawamoto, Tomohiro, Okaniwa, Masanori
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674098/
https://ncbi.nlm.nih.gov/pubmed/26649895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144675
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