Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

The molecular mechanism responsible that determines cell fate after mitotic slippage is unclear. Here we investigate the post-mitotic effects of different mitotic aberrations—misaligned chromosomes produced by CENP-E inhibition and monopolar spindles resulting from Eg5 inhibition. Eg5 inhibition in...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Nakayama, Yusuke, Nambu, Tadahiro, Morishita, Daisuke, Kawamoto, Tomohiro, Miyamoto, Maki, Hirayama, Takaharu, Okaniwa, Masanori, Banno, Hiroshi, Ishikawa, Tomoyasu, Kandori, Hitoshi, Iwata, Kentaro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506520/
https://ncbi.nlm.nih.gov/pubmed/26144554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8668
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