Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

The molecular mechanism responsible that determines cell fate after mitotic slippage is unclear. Here we investigate the post-mitotic effects of different mitotic aberrations—misaligned chromosomes produced by CENP-E inhibition and monopolar spindles resulting from Eg5 inhibition. Eg5 inhibition in...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Nakayama, Yusuke, Nambu, Tadahiro, Morishita, Daisuke, Kawamoto, Tomohiro, Miyamoto, Maki, Hirayama, Takaharu, Okaniwa, Masanori, Banno, Hiroshi, Ishikawa, Tomoyasu, Kandori, Hitoshi, Iwata, Kentaro
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Pub. Group 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506520/
https://ncbi.nlm.nih.gov/pubmed/26144554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8668
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