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Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal cell carcinoma: a retrospective analysis with independent validation

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) displays a variety of clinical behaviors. However, the molecular genetic events driving these behaviors are unknown. We discovered that BAP1 is mutated in approximately 15% of ccRCC and that BAP1 and PBRM1 mutations are largely mutually exclusive....

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Dettagli Bibliografici
Pubblicato in:Lancet Oncol
Autori principali: Kapur, Payal, Peña-Llopis, Samuel, Christie, Alana, Zhrebker, Leah, Pavía-Jiménez, Andrea, Rathmell, W. Kimryn, Xie, Xian-Jin, Brugarolas, James
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674067/
https://ncbi.nlm.nih.gov/pubmed/23333114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(12)70584-3
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