BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

BACKGROUND: BAP1 and PBRM1 are frequently mutated in primary clear cell renal cell carcinoma (ccRCC) tumors; however, the frequency and clinical relevance of these mutations in metastatic ccRCC tumors is unknown. Additionally, while intra-tumor heterogeneity has been shown to be common in primary cc...

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Udgivet i:BMC Urol
Main Authors: Eckel-Passow, Jeanette E., Serie, Daniel J., Cheville, John C., Ho, Thai H., Kapur, Payal, Brugarolas, James, Thompson, R. Houston, Leibovich, Bradley C., Kwon, Eugene D., Joseph, Richard W., Parker, Alexander S.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361787/
https://ncbi.nlm.nih.gov/pubmed/28327121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12894-017-0209-3
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