BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

BACKGROUND: BAP1 and PBRM1 are frequently mutated in primary clear cell renal cell carcinoma (ccRCC) tumors; however, the frequency and clinical relevance of these mutations in metastatic ccRCC tumors is unknown. Additionally, while intra-tumor heterogeneity has been shown to be common in primary cc...

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Pubblicato in:BMC Urol
Autori principali: Eckel-Passow, Jeanette E., Serie, Daniel J., Cheville, John C., Ho, Thai H., Kapur, Payal, Brugarolas, James, Thompson, R. Houston, Leibovich, Bradley C., Kwon, Eugene D., Joseph, Richard W., Parker, Alexander S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361787/
https://ncbi.nlm.nih.gov/pubmed/28327121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12894-017-0209-3
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