Loss of BAP1 Protein Expression Is an Independent Marker of Poor Prognosis in patients with Low Risk Clear Cell Renal Cell Carcinoma

PURPOSE: The majority of patients diagnosed with clear cell renal cell carcinoma (ccRCC) have low-risk disease with a <10% chance of ccRCC-specific death. DNA sequencing revealed that mutations in BAP1 occur in 5–15% of ccRCC and are associated with poor outcomes. The vast majority of BAP1 mutati...

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Autori principali: Joseph, Richard W., Kapur, Payal, Serie, Daniel J., Eckel-Passow, Jeanette E., Parasramka, Mansi, Ho, Thai, Cheville, John C., Frenkel, Eugene, Rakheja, Dinesh, Brugarolas, James, Parker, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075029/
https://ncbi.nlm.nih.gov/pubmed/24382589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28521
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