Modeling Renal Cell Carcinoma in mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade

Clear cell renal cell carcinoma (ccRCC) is characterized by BAP1 and PBRM1 mutation, which are associated with tumors of different grade and prognosis. However, whether BAP1 and PBRM1 loss causes ccRCC and determines tumor grade is unclear. We conditionally targeted Bap1 and Pbrm1 (with Vhl) in the...

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Publié dans:Cancer Discov
Auteurs principaux: Gu, Yi-Feng, Cohn, Shannon, Christie, Alana, McKenzie, Tiffani, Wolff, Nicholas, Do, Quyen N., Madhuranthakam, Ananth J., Pedrosa, Ivan, Wang, Tao, Dey, Anwesha, Busslinger, Meinrad, Xie, Xian-Jin, Hammer, Robert E., McKay, Renée M., Kapur, Payal, Brugarolas, James
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540776/
https://ncbi.nlm.nih.gov/pubmed/28473526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0292
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