Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation

Apoptosis resistance in activated neutrophils is known to be associated with collateral damage of surrounding tissue, as well as immune and organ dysfunction. Thus, the safe removal of neutrophils by apoptosis induction represents a prerequisite for the resolution of inflammation. Here, we report th...

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Veröffentlicht in:J Leukoc Biol
Hauptverfasser: Hornstein, Tamara, Lehmann, Sarah, Philipp, Denise, Detmer, Susanne, Hoffmann, Michèle, Peter, Christoph, Wesselborg, Sebastian, Unfried, Klaus, Windolf, Joachim, Flohé, Sascha, Paunel-Görgülü, Adnana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2016
Schlagworte:
Inflammation, Extracellular Mediators, & Effector Molecules
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673481/
https://ncbi.nlm.nih.gov/pubmed/26310832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A1114-537RR
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