Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice

INTRODUCTION: Although the formation of neutrophil (PMN) extracellular traps (NETs) has been detected during infection and sepsis, their role in vivo is still unclear. This study was performed in order to evaluate the influence of NETs depletion by administration of recombinant human (rh)DNase on ba...

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Bibliographische Detailangaben
Hauptverfasser: Meng, Wei, Paunel-Görgülü, Adnana, Flohé, Sascha, Hoffmann, Almuth, Witte, Ingo, MacKenzie, Colin, Baldus, Stephan E, Windolf, Joachim, Lögters, Tim T
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580722/
https://ncbi.nlm.nih.gov/pubmed/22835277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc11442
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