Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling

Histone acetylation marks have an important role in controlling gene expression and are removed by histone deacetylases (HDACs). These marks are read by bromodomain and extra-terminal (BET) proteins and novel inhibitiors of these proteins are currently in clinical development. Inhibitors of HDAC and...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Heinemann, Anja, Cullinane, Carleen, De Paoli-Iseppi, Ricardo, Wilmott, James S., Gunatilake, Dilini, Madore, Jason, Strbenac, Dario, Yang, Jean Y., Gowrishankar, Kavitha, Tiffen, Jessamy C., Prinjha, Rab K., Smithers, Nicholas, McArthur, Grant A., Hersey, Peter, Gallagher, Stuart J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2015
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673282/
https://ncbi.nlm.nih.gov/pubmed/26087189
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