Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

The epigenetic modifier EZH2 is part of the polycomb repressive complex that suppresses gene expression via histone methylation. Activating mutations in EZH2 are found in a subset of melanoma that contributes to disease progression by inactivating tumor suppressor genes. In this study we have target...

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Udgivet i:Oncotarget
Main Authors: Tiffen, Jessamy C., Gunatilake, Dilini, Gallagher, Stuart J., Gowrishankar, Kavitha, Heinemann, Anja, Cullinane, Carleen, Dutton-Regester, Ken, Pupo, Gulietta M., Strbenac, Dario, Yang, Jean Y., Madore, Jason, Mann, Graham J., Hayward, Nicholas K., McArthur, Grant A., Filipp, Fabian V., Hersey, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694971/
https://ncbi.nlm.nih.gov/pubmed/26304929
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