Ca(2+) influx-mediated dilation of the endoplasmic reticulum and c-FLIP(L) downregulation trigger CDDO-Me–induced apoptosis in breast cancer cells

The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9(11)-dien-C28-methyl ester (CDDO-Me) is considered a promising anti-tumorigenic compound. In this study, we show that treatment with CDDO-Me induces progressive endoplasmic reticulum (ER)-derived vacuolation in various breast cancer cells and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jeong, Soo Ah, Kim, In Young, Lee, A Reum, Yoon, Mi Jin, Cho, Hyeseong, Lee, Jong-Soo, Choi, Kyeong Sook
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673258/
https://ncbi.nlm.nih.gov/pubmed/26053096
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