Release of Ca(2+) from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells

Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine”, is known to have anticancer activity, but its underlying mechanism is not completely understood. In this study, we show that celastrol kills several breast and colon cancer cell lines by induction of paraptosis, a cell death m...

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Bibliographic Details
Main Authors: Yoon, Mi Jin, Lee, A Reum, Jeong, Soo Ah, Kim, You-Sun, Kim, Jin Yeop, Kwon, Yong-Jun, Choi, Kyeong Sook
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196165/
https://ncbi.nlm.nih.gov/pubmed/25149175
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