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Coupling of endoplasmic reticulum stress to CDDO-Me-induced upregulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation
The synthetic triterpenoid methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate (CDDO-Me) is in Phase I clinical trials as a novel cancer therapeutic agent. We previously demonstrated that CDDO-Me induces c-Jun N-terminal kinase (JNK)-dependent death receptor 5 (DR5) expression and augments death recepto...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597446/ https://ncbi.nlm.nih.gov/pubmed/18794136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1318 |
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