Bcl-2(high) mantle cell lymphoma cells are sensitized to acadesine with ABT-199

Acadesine is a nucleoside analogue with known activity against B-cell malignancies. Herein, we showed that in mantle cell lymphoma (MCL) cells acadesine induced caspase-dependent apoptosis through turning on the mitochondrial apoptotic machinery. At the molecular level, the compound triggered the ac...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Montraveta, Arnau, Xargay-Torrent, Sílvia, Rosich, Laia, López-Guerra, Mònica, Roldán, Jocabed, Rodríguez, Vanina, Lee-Vergés, Eriong, de Frías, Mercè, Campàs, Clara, Campo, Elias, Roué, Gaël, Colomer, Dolors
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673257/
https://ncbi.nlm.nih.gov/pubmed/26110568
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