F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

Kruppel-like factor 4 (KLF4), a member of the KLF family of transcription factors, has been considered as a crucial tumor suppressor in hepatocellular carcinoma (HCC). Using affinity purifications and mass spectrometry, we identified FBXO22, Cullin1 and SKP1 as interacting proteins of KLF4. We demon...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Tian, Xin, Dai, Shundong, Sun, Jing, Jin, Guojiang, Jiang, Shenyi, Meng, Fandong, Li, Yan, Wu, Di, Jiang, Youhong
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673198/
https://ncbi.nlm.nih.gov/pubmed/26087183
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker