F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

Kruppel-like factor 4 (KLF4), a member of the KLF family of transcription factors, has been considered as a crucial tumor suppressor in hepatocellular carcinoma (HCC). Using affinity purifications and mass spectrometry, we identified FBXO22, Cullin1 and SKP1 as interacting proteins of KLF4. We demon...

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Publicat a:Oncotarget
Autors principals: Tian, Xin, Dai, Shundong, Sun, Jing, Jin, Guojiang, Jiang, Shenyi, Meng, Fandong, Li, Yan, Wu, Di, Jiang, Youhong
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673198/
https://ncbi.nlm.nih.gov/pubmed/26087183
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