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The F-box Protein FBXO44 Mediates BRCA1 Ubiquitination and Degradation
BRCA1 mutations account for a significant proportion of familial breast and ovarian cancers. In addition, reduced BRCA1 protein is associated with sporadic cancer cases in these tissues. At the cellular level, BRCA1 plays a critical role in multiple cellular functions such as DNA repair and cell cyc...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510804/ https://ncbi.nlm.nih.gov/pubmed/23086937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407106 |
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