The F-box Protein FBXO44 Mediates BRCA1 Ubiquitination and Degradation

BRCA1 mutations account for a significant proportion of familial breast and ovarian cancers. In addition, reduced BRCA1 protein is associated with sporadic cancer cases in these tissues. At the cellular level, BRCA1 plays a critical role in multiple cellular functions such as DNA repair and cell cyc...

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Bibliografski detalji
Glavni autori: Lu, Yunzhe, Li, Jiezhi, Cheng, Dongmei, Parameswaran, Balaji, Zhang, Shaohua, Jiang, Zefei, Yew, P. Renee, Peng, Junmin, Ye, Qinong, Hu, Yanfen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Protein Synthesis and Degradation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510804/
https://ncbi.nlm.nih.gov/pubmed/23086937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407106
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