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Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras

The pro-survival factor Bcl-2 and its family members are critical determinants of the threshold of the susceptibility of cells to apoptosis. Studies are shown that cells harboring an oncogenic ras were extremely sensitive to the inhibition of protein kinase C (PKC) and Bcl-2 could antagonize this ap...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Peng, Bo, Ganapathy, Suthakar, Shen, Ling, Huang, Junchi, Yi, Bo, Zhou, Xiaodong, Dai, Wei, Chen, Changyan
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673166/
https://ncbi.nlm.nih.gov/pubmed/26041886
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