EGFR blockade prevents glioma escape from BRAF(V600E) targeted therapy

Mutational activation of BRAF (BRAF(V600E)) occurs in pediatric glioma and drives aberrant MAPK signaling independently of upstream cues. Targeted monotherapy against BRAF(V600E) displays efficacy in pre-clinical models of glioma, however xenograft tumors adapt rapidly and escape from the growth-inh...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Yao, Tsun-Wen, Zhang, Jie, Prados, Michael, Weiss, William A., James, C. David, Nicolaides, Theodore
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2015
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673141/
https://ncbi.nlm.nih.gov/pubmed/26023796
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