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TARGETING RESISTANCE PATHWAYS IN BRAF-MUTANT PEDIATRIC GLIOMAS
BACKGROUND: Mutational activation of BRAF is a common finding in pediatric gliomas. As many as 14% of pediatric high grade glioma and up to 66% of certain subtypes of low grade pediatric glioma contain the BRAFV600E mutation. Small molecule inhibitors that selectively target BRAFV600E, and that are...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144562/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.18 |
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