EGFR blockade prevents glioma escape from BRAF(V600E) targeted therapy

Mutational activation of BRAF (BRAF(V600E)) occurs in pediatric glioma and drives aberrant MAPK signaling independently of upstream cues. Targeted monotherapy against BRAF(V600E) displays efficacy in pre-clinical models of glioma, however xenograft tumors adapt rapidly and escape from the growth-inh...

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Publicado en:Oncotarget
Autores principales: Yao, Tsun-Wen, Zhang, Jie, Prados, Michael, Weiss, William A., James, C. David, Nicolaides, Theodore
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673141/
https://ncbi.nlm.nih.gov/pubmed/26023796
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