The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer

Over 30% of ERα breast cancer patients develop relapses and progress to metastatic disease despite treatment with endocrine therapies. The pioneer factor PBX1 translates epigenetic cues and mediates estrogen induced ERα binding. Here we demonstrate that PBX1 plays a central role in regulating the ER...

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Pubblicato in:Oncotarget
Autori principali: Magnani, Luca, Patten, Darren K., Nguyen, Van T.M., Hong, Sung-Pil, Steel, Jennifer H., Patel, Naina, Lombardo, Ylenia, Faronato, Monica, Gomes, Ana R., Woodley, Laura, Page, Karen, Guttery, David, Primrose, Lindsay, Garcia, Daniel Fernandez, Shaw, Jacqui, Viola, Patrizia, Green, Andrew, Nolan, Christopher, Ellis, Ian O., Rakha, Emad A., Shousha, Sami, Lam, Eric W.-F., Győrffy, Balázs, Lupien, Mathieu, Coombes, R. Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673133/
https://ncbi.nlm.nih.gov/pubmed/26215677
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