The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer

Over 30% of ERα breast cancer patients develop relapses and progress to metastatic disease despite treatment with endocrine therapies. The pioneer factor PBX1 translates epigenetic cues and mediates estrogen induced ERα binding. Here we demonstrate that PBX1 plays a central role in regulating the ER...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Magnani, Luca, Patten, Darren K., Nguyen, Van T.M., Hong, Sung-Pil, Steel, Jennifer H., Patel, Naina, Lombardo, Ylenia, Faronato, Monica, Gomes, Ana R., Woodley, Laura, Page, Karen, Guttery, David, Primrose, Lindsay, Garcia, Daniel Fernandez, Shaw, Jacqui, Viola, Patrizia, Green, Andrew, Nolan, Christopher, Ellis, Ian O., Rakha, Emad A., Shousha, Sami, Lam, Eric W.-F., Győrffy, Balázs, Lupien, Mathieu, Coombes, R. Charles
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673133/
https://ncbi.nlm.nih.gov/pubmed/26215677
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