Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

Endocrine therapies target the activation of the oestrogen receptor alpha (ERα) via distinct mechanisms, but it is not clear whether breast cancer cells can adapt to treatment using drug-specific mechanisms. Here we demonstrate that resistance emerges via drug-specific epigenetic reprogramming. Resi...

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Foilsithe in:Nat Commun
Main Authors: Nguyen, Van T. M., Barozzi, Iros, Faronato, Monica, Lombardo, Ylenia, Steel, Jennifer H., Patel, Naina, Darbre, Philippa, Castellano, Leandro, Győrffy, Balázs, Woodley, Laura, Meira, Alba, Patten, Darren K., Vircillo, Valentina, Periyasamy, Manikandan, Ali, Simak, Frige, Gianmaria, Minucci, Saverio, Coombes, R. Charles, Magnani, Luca
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Pub. Group 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674692/
https://ncbi.nlm.nih.gov/pubmed/26610607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10044
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