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Canine Osteosarcoma Cells Exhibit Resistance to Aurora Kinase Inhibitors

We evaluated the effect of Aurora kinase inhibitors AZD1152 and VX680 on canine osteosarcoma cell lines. Cytotoxicity was seen in all four cell lines; however, half-maximal inhibitory concentrations were significantly higher than in human and canine leukemia cells. AZD1152 reduced Aurora kinase B ph...

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Bibliografski detalji
Izdano u:Vet Comp Oncol
Glavni autori: Cannon, Claire M., Pozniak, John, Scott, Milcah C., Ito, Daisuke, Gorden, Brandi H., Graef, Ashley J., Modiano, Jaime F.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672990/
https://ncbi.nlm.nih.gov/pubmed/23410058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/vco.12018
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