Arginase Treatment Prevents the Recovery of Canine Lymphoma and Osteosarcoma Cells Resistant to the Toxic Effects of Prolonged Arginine Deprivation

Rapidly growing tumor cells require a nutrient-rich environment in order to thrive, therefore, restricting access to certain key amino acids, such as arginine, often results in the death of malignant cells, which frequently display defective cell cycle check-point control. Healthy cells, by contrast...

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Detalhes bibliográficos
Main Authors: Wells, James W., Evans, Christopher H., Scott, Milcah C., Rütgen, Barbara C., O'Brien, Timothy D., Modiano, Jaime F., Cvetkovic, Goran, Tepic, Slobodan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554772/
https://ncbi.nlm.nih.gov/pubmed/23365669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054464
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