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Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing

RNA polymerase II (RNAPII) transcription elongation is a highly regulated process that greatly influences mRNA levels as well as pre-mRNA splicing. Despite many studies in vitro, how chromatin modulates RNAPII elongation in vivo is still unclear. Here, we show that a decrease in the level of availab...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jimeno-González, Silvia, Payán-Bravo, Laura, Muñoz-Cabello, Ana M., Guijo, Macarena, Gutierrez, Gabriel, Prado, Félix, Reyes, José C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672771/
https://ncbi.nlm.nih.gov/pubmed/26578803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506760112
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