Capturing the direct binding of CFTR correctors to CFTR using click chemistry

Cystic fibrosis (CF) is a lethal genetic disease caused by the loss or dysfunction of the CF transmembrane conductance regulator (CFTR) channel. F508del is the most prevalent mutation of the CFTR gene and encodes a protein defective in folding and processing. VX-809 has been reported to facilitate t...

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Publicat a:Chembiochem
Autors principals: Sinha, Chandrima, Zhang, Weiqiang, Moon, Chang Suk, Actis, Marcelo, Yarlagadda, Sunitha, Arora, Kavisha, Woodroofe, Koryse, Clancy, John P., Lin, Songbai, Ziady, Assem G., Frizzell, Raymond, Fujii, Naoaki, Naren, Anjaparavanda P.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672727/
https://ncbi.nlm.nih.gov/pubmed/26227551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500123
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