Stabilizing Rescued Surface-Localized ΔF508 CFTR by Potentiation of Its Interaction with Na(+)/H(+) Exchanger Regulatory Factor 1

[Image: see text] Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in CFTR, a plasma-membrane-localized anion channel. The most common mutation in CFTR, deletion of phenylalanine at residue 508 (ΔF508), causes misfolding of CFTR resulting in little or no protein at the plasma...

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Detalhes bibliográficos
Main Authors: Arora, Kavisha, Moon, Changsuk, Zhang, Weiqiang, Yarlagadda, Sunitha, Penmatsa, Himabindu, Ren, Aixia, Sinha, Chandrima, Naren, Anjaparavanda P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081048/
https://ncbi.nlm.nih.gov/pubmed/24945463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401263h
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