Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme

Genomes of all free-living organisms encode the enzyme dUTPase (dUTP pyrophosphatase), which plays a key role in preventing uracil incorporation into DNA. In the present paper, we describe the biochemical and structural characterization of DUT1 (Saccharomyces cerevisiae dUTPase). The hydrolysis of d...

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Foilsithe in:Biochem J
Main Authors: Tchigvintsev, Anatoli, Singer, Alexander U., Flick, Robert, Petit, Pierre, Brown, Greg, Evdokimova, Elena, Savchenko, Alexei, Yakunin, Alexander F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671291/
https://ncbi.nlm.nih.gov/pubmed/21548881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110304
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