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Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme

Genomes of all free-living organisms encode the enzyme dUTPase (dUTP pyrophosphatase), which plays a key role in preventing uracil incorporation into DNA. In the present paper, we describe the biochemical and structural characterization of DUT1 (Saccharomyces cerevisiae dUTPase). The hydrolysis of d...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem J
Prif Awduron: Tchigvintsev, Anatoli, Singer, Alexander U., Flick, Robert, Petit, Pierre, Brown, Greg, Evdokimova, Elena, Savchenko, Alexei, Yakunin, Alexander F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671291/
https://ncbi.nlm.nih.gov/pubmed/21548881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110304
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